Experimental Induction of Caprylate‐Dependent Albumin Antibodies

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Abstract
To provide evidence for the immune nature of the albumin agglutination phenomenon or caprylate dependent albumin agglutinins (CDAA), rabbits were injected with native serum that was incubated in a solution of sodium caprylate. Two of 3 rabbits responded with the production of CDAA, which in vitro behaved identical to human antisera. Human cells were agglutinated only when caprylate stabilized albumin was added to the red blood cell/serum mixture or when caprylate free albumin plus sodium caprylate were used. The CDAA failed to agglutinate rabbit cells, although human adult and cord cells were agglutinated. CDAA probably represent an immune response to native albumin that was altered by caprylate.