Overfeeding as a Stress

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Abstract
Apart from adiposity, overnutrition causes metabolic and structural adaptations in a variety of tissues. Although initially beneficial, such adaptation may finally predispose to pathologic changes. It is suggested that prolonged overproduction of insulin may be a factor in the increased incidence of diabetes in obesity. Possible causes for abnormal tubular hyperplasia observed in the kidneys of obese rats are considered in relation to the frequency of renal diseases in the obese animals.