OXYGEN INHIBITION OF GROWTH OF MYCOBACTERIUM TUBERCULOSIS

Publisher Website
Google Scholar
Abstract
Gottlieb , S. F. (Linde Division, Union Carbide Corporation, Tonawanda, N.Y.), Noel R. Rose, Jerome Maurizi, and Edward H. Lanphier . Oxygen inhibition of growth of Mycobacterium tuberculosis . J. Bacteriol. 87: 838–843. 1964.—Continuous or intermittent exposure to 3 atm of oxygen in the presence or absence of 40 mm of Hg CO 2 resulted in marked delay or inhibition of growth of Mycobacterium tuberculosis . This inhibition was more pronounced with newly inoculated cultures, as compared to young, actively growing cultures. Oxygen inhibition of growth was observed on both Lowenstein-Jensen and blood agar media. Bacteriostatic effects of oxygen are a direct function of exposure time. A more marked effect of oxygen was observed in the presence of isoniazid, streptomycin, or p -aminosalicyclic acid.