HEPATIC CHANGES IN LATE CANINE ENDOTOXIN SHOCK

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Abstract
Patho-morphological liver lesions in late stages of canine [Escherichia coli] endotoxin [etox] shock were studied with EM and light microscopy. Light microscopic lesions included sinusoidal dilatations with accumulation of red cells and leukocytes, varying sinusoidal lining damage, microthrombi and widening of the Disse space. Necrotic foci were in some cases recognized within a varying lobuli number, at times in the centrilobular areas. EM revealed severe hepatocytic damage. These lesions included formations of blebs and other surface protrusions corresponding to cytoplasmic ecdysis. The resulting cytoplasmic fragments seemed frequently to enter the sinusoids. Severe disturbances observed in the proteolytic enzyme systems of plasma during etox shock may be influenced by the hepatic parenchymal changes observed.