THE INTEGRITY OF TUBULAR CELL FUNCTION AFTER PRESERVATION IN COLLINS' OR SACKS' SOLUTION

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Abstract
Collins'' solution is an excellent medium for kidney preservation by simple cold storage before transplantation. Efforts by Sacks et al. to improve this technique by modifying the composition seemed promising. A comparison between ability of these 2 media to preserve the tubular cell was attempted. The viability of the tubular cells was evaluated by measuring the 125I Hippuran uptake in cortex slices taken from [rabbit] kidneys preserved for 24 and 48 h in the respective solutions. Kidneys exposed to and kidneys not exposed to warm ischemia were used. Collins'' solution was superior in protecting the cell function. Intracellular edema during preservation was greater after preservation in this solution as compared with cells preserved in Sacks'' solution.