Synthesis of 2‘β-Deoxy-[8-13C;amino,9-15N2]adenosine: Unusual Annulation Conditions To Assemble the Purine Core
- 27 May 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 64 (13) , 4685-4689
- https://doi.org/10.1021/jo9824753
Abstract
Synthesis of 2‘β-Deoxy-[8-13C;amino,9-15N2]adenosine has been accomplished using a five-step process which employs a novel annulation of [13C]formamide [N-(4-[15N]amino-6-chloro-5-pyrimidinyl)] 2. To effect this dehydration, a complex of triethyl phosphite and TiCl2(i-OPr)2 was used. 6-Chloro-[8-13C; 9-15N]purine was then converted in two steps to 2‘β-deoxy-[8-13C;amino,9-15N2]adenosine.Keywords
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