Mitochondrial tumour suppressors: a genetic and biochemical update
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- 1 November 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (11) , 857-866
- https://doi.org/10.1038/nrc1737
Abstract
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal cell carcinomas. Here we review recent advances in the field of mitochondrial tumour suppressors, the biochemical pathway that links mitochondrial dysfunction with tumorigenesis, and potential therapeutic approaches to these malignancies.Keywords
This publication has 90 references indexed in Scilit:
- Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from ApoptosisCancer Research, 2005
- mtDNA mutations increase tumorigenicity in prostate cancerProceedings of the National Academy of Sciences, 2005
- Why do cancers have high aerobic glycolysis?Nature Reviews Cancer, 2004
- Architecture of Succinate Dehydrogenase and Reactive Oxygen Species GenerationScience, 2003
- Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial ParagangliomaAmerican Journal of Human Genetics, 2001
- High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selectionNature Genetics, 2001
- Mutations in SDHC cause autosomal dominant paraganglioma, type 3Nature Genetics, 2000
- Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary ParagangliomaScience, 2000
- Somatic mutations of the mitochondrial genome in human colorectal tumoursNature Genetics, 1998
- On the Origin of Cancer CellsScience, 1956