An evaluation of the algorithms for determining local cerebral metabolic rates of glucose using positron emission tomography dynamic data
- 1 January 1995
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Medical Imaging
- Vol. 14 (4) , 697-710
- https://doi.org/10.1109/42.476111
Abstract
Measurement of the local cerebral metabolic rate of glucose (LCMRGlc) and the individual rate constant parameters of the [(18 )F]2-fluoro-2-deoxy-D-glucose (FDG) model can provide a clearer understanding and insight to the physiological processes in the human brain, and a quicker and more accurate means of diagnosis in clinical applications. A systematic study using simulated and clinical tissue time activity data is presented to evaluate several existing and newly developed major algorithms used for determining LCMRGlc and the individual rate constants from positron emission tomography dynamic data. The computational and statistical properties of the autoradiographic approach, weighted and unweighted nonlinear least squares methods, Patlak graphic approach, weighted integration method, linear least squares and generalized linear least squares methods are investigated and discussed in this paper.Keywords
This publication has 17 references indexed in Scilit:
- An unbiased parametric imaging algorithm for nonuniformly sampled biomedical system parameter estimationIEEE Transactions on Medical Imaging, 1996
- A study on statistically reliable and computationally efficient algorithms for generating local cerebral blood flow parametric images with positron emission tomographyIEEE Transactions on Medical Imaging, 1993
- Models for computer simulation studies of input functions for tracer kinetic modeling with positron emission tomographyInternational Journal of Bio-Medical Computing, 1993
- A New Approach of Weighted Integration Technique Based on Accumulated Images Using Dynamic PET and H152OJournal of Cerebral Blood Flow & Metabolism, 1991
- Effects of Temporal Sampling, Glucose Metabolic Rates, and Disruptions of the Blood—Brain Barrier on the FDG Model with and without a Vascular Compartment: Studies in Human Brain Tumors with PETJournal of Cerebral Blood Flow & Metabolism, 1986
- Weighted Integration Method for Local Cerebral Blood Flow Measurements with Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1986
- Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. GeneralizationsJournal of Cerebral Blood Flow & Metabolism, 1985
- On the Construction of Functional Maps in Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1984
- Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake DataJournal of Cerebral Blood Flow & Metabolism, 1983
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977