Improved method for the synthesis of o-glycosylated fmoc amino acids to be used in solid-phase glycopeptide synthesis (Fmoc = fluoren-9-ylmethoxycarbonyl)

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Abstract
The building blocks O1-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-Nα-(fluoren-9-ylmethoxycarbonyl)serine (5) and O1-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-Nα-(fluoren-9-ylmethoxycarbonyl)threonine (6) for use in solid-phase glycopeptide synthesis can be obtained via their ally esters by mild treatment with tetrakis(triphenylphosphine)palladium(0) and tributyltin hydride with no Fmoc elimination or sugar cleavage or anomerization.