Lessons from natural molecules
Top Cited Papers
- 15 December 2004
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 432 (7019) , 829-837
- https://doi.org/10.1038/nature03194
Abstract
Natural products have inspired chemists and physicians for millennia. Their rich structural diversity and complexity has prompted synthetic chemists to produce them in the laboratory, often with therapeutic applications in mind, and many drugs used today are natural products or natural-product derivatives. Recent years have seen considerable advances in our understanding of natural-product biosynthesis. Coupled with improvements in approaches for natural-product isolation, characterization and synthesis, these could be opening the door to a new era in the investigation of natural products in academia and industry.Keywords
This publication has 77 references indexed in Scilit:
- Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193- N -Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewisy and Eliminates Lewisy-Positive Human Carcinoma Cells and XenograftsClinical Cancer Research, 2004
- AknK Is an l-2-Deoxyfucosyltransferase in the Biosynthesis of the Anthracycline Aclacinomycin ABiochemistry, 2004
- Generating Diverse Skeletons of Small Molecules CombinatoriallyScience, 2003
- Antibiotic Glycosyltransferases: Antibiotic Maturation and Prospects for ReprogrammingJournal of Medicinal Chemistry, 2003
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus SalinosporaAngewandte Chemie International Edition in English, 2003
- Nodulisporic Acids C, C1, and C2: A Series of D-Ring-Opened Nodulisporic Acids from the Fungus Nodulisporium sp.Journal of Natural Products, 2002
- Biosynthesis of the Enediyne Antitumor Antibiotic C-1027Science, 2002
- Taxol biosynthetic genesPhytochemistry, 2001
- Type I polyketide biosynthesis in bacteria (Part B) (1995 to mid-2000)Natural Product Reports, 2001