FUNCTIONAL INTRASPLENIC OVARIAN TRANSPLANTS IN MONKEYS1

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Abstract
The inactivation of estrogens by the liver has been generally assumed for animals of all species although few species have been investigated with this question in view. Zondek (1934) first demonstrated that rat’s liver destroyed the normally occurring estrogens and numerous investigators have extended this observation to other species of rodents. And, conversely, Talbot (1939) by chemically destroying liver function showed a subsequent rise in circulating estrogens. However, few experiments have been conducted on the hepatic inactivation of estrogens by primates. Twombly and Taylor (1942) observed that in 17 of 22 tests in which estradiol was incubated with human liver there was little inactivation of the hormone. The hepatic tissue from the other five human donors was about half as effective in destroying estradiol as was rat’s liver. In the monkey, intrasplenic implantation of pellets of estrone and estradiol was followed by reddening of the sex-skin and alteration of the vaginal smear, as promptly and with the same intensity