Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
Open Access
- 1 June 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 339 (6224) , 446-451
- https://doi.org/10.1038/339446a0
Abstract
Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man.Keywords
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