FURTHER STUDIES ON THE METABOLISM OF GLUCOSE AND THE FORMATION OF CORTICOSTEROIDS IN VITRO
- 1 October 1959
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 37 (10) , 1209-1214
- https://doi.org/10.1139/o59-135
Abstract
Glucose, adenosine, uridine, and reduced triphosphopyridine-nucleotide (TPNH) significantly increase the effect of corticotrophin (ACTH) on the formation of steroids by rat adrenals in vitro. This effect of glucose is inhibited by 2-deoxyglucose. Inhibition is overcome by TPNH. During the incubation of adrenal fragments, but not of intact glands, TPN-dependent dehydrogenases leak into the medium.Keywords
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