Effect of Reserpine on Cardiac Function During Thiopental-Cyclopropane Anesthesia in the Dog

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Abstract
The effect of thiopental-cyclopropane anesthesia on cardiac output, heart rate, mean arterial blood pressure, and rate of rise of left ventricular pressure in trained dogs before and after reserpine was investigated. Each dog served as his own control both for the effect of anesthesia (conscious versus anesthetized) and the effect of reserpine on the response to anesthesia (pre-reserpine versus post-reserpine effects of anesthesia). Anesthesia caused an increase in mean arterial blood pressure and heart rate both before and after reserpine. The depressant effect of anesthesia on the rate of rise of left ventricular pressure was not altered significantly by reserpine. Cardiac output was depressed by anesthesia. The degree of depression was significantly greater following very large doses of reserpine.