Remarks on the supramolecular organization of the glycolytic system in vivo

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Abstract
The great latent catalytic capacity, manifested at the extremely high intracellular concentrations and in large apparent k cat/K m values, of the glycolytic enzymes on the one hand and their tendency in experiments in vitro to form functionally-specific flux-enhancing (channeling) complexes on the other, is considered and discussed as an apparent discrepancy. A random association of glycolytic enzymes in vivo is probable.