Potency Difference between the Zwitterion Form and the Cation Forms of Tetrodotoxin
- 23 June 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3782) , 1625-1627
- https://doi.org/10.1126/science.156.3782.1625
Abstract
Tetrodotoxin can exist as a zwitterion or two different cations in aqueous solutions. The cation forms are more potent in nerve block. Thus the lactone-hemilactal configuration of tetrodotoxin influences potency. Electrostatic attraction, hydrogen bonding, and intermolecular hemilactal formation are possible mechanisms of interaction with membrane receptors.This publication has 5 references indexed in Scilit:
- Tetrodotoxin Does Not Block Excitation from Inside the Nerve MembraneScience, 1966
- TetrodotoxinTetrahedron, 1965
- The structure of tetrodotoxinPure and Applied Chemistry, 1964
- Tetrodotoxin. VII. On the Structures of Tetrodotoxin and its DerivativesCHEMICAL & PHARMACEUTICAL BULLETIN, 1964
- OBSERVATIONS ON THE PROPERTIES OF THE EPINEURIUM OF FROG NERVEPublished by Cold Spring Harbor Laboratory ,1952