−11 Mutation in theampCPromoter Increasing Resistance to β-Lactams in a ClinicalEscherichia coliStrain
Open Access
- 1 October 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (10) , 3265-3267
- https://doi.org/10.1128/aac.46.10.3265-3267.2002
Abstract
A mutation was discovered in the Pribnow box of theampCpromoter in a clinicalEscherichia colistrain. This −11 C-to-T transition created a perfect homology with the −10 consensus sequence. The new promoter was cloned upstream of thecatgene of pKK232-8 and induced a sixfold increase in promoter strength.Keywords
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