Ability of Thymosin to Decrease in Vivo and in Vitro Suppressor Cell Activity in Tumor Bearing Mice and Cancer Patients
- 1 January 1980
- book chapter
- Published by Springer Nature
- Vol. 75, 110-114
- https://doi.org/10.1007/978-3-642-81491-4_18
Abstract
We have demonstrated that splenic lymphocytes from normal syngeneic animals can stimulate tumor growth. This effect is T-cell dependent. Preincubation of these lymphocytes with thymosin not only blocks facilitated tumor growth but can induce a significant reduction of local tumor growth and number of pulmonary metastases. Furthermore, thymosin can also block the expression of suppressor activity of lymphocytes either stimulated by Con A or originating from various advanced solid tumor bearing patients. These results therefore suggest that thymosin is able to modulate, directly or indirectly, functional expression of suppressor cells.Keywords
This publication has 8 references indexed in Scilit:
- CURRENT STATUS OF THYMOSIN RESEARCH: EVIDENCE FOR THE EXISTENCE OF A FAMILY OF THYMIC FACTORS THAT CONTROL T‐CELL MATURATION*Annals of the New York Academy of Sciences, 1979
- THE MODE OF ACTION OF THYMIC HORMONESAnnals of the New York Academy of Sciences, 1979
- EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPYAnnals of the New York Academy of Sciences, 1979
- NEW APPROACHES TO THE EVALUATION OF IMMUNOMODULATION BY THYMIC HORMONESAnnals of the New York Academy of Sciences, 1979
- THYMOSIN MODULATION OF SUPPRESSOR FUNCTION IN MICE AND MAN.Annals of the New York Academy of Sciences, 1979
- Human Autologous Rosettes. II. Prognostic Significance of Variations in Autologous Rosette-Forming Cells in the Peripheral Blood of Cancer Patients2JNCI Journal of the National Cancer Institute, 1979
- Human autologous rosettesCellular Immunology, 1979
- Suppressor Cells in Neoplastic DiseaseJNCI Journal of the National Cancer Institute, 1978