Studies on Peptides. XII.Synthesis of the Decapeptide corresponding to the C-Terminal Portion of β-Melanocyte-stimulating Hormone
- 1 January 1967
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 15 (3) , 270-278
- https://doi.org/10.1248/cpb.15.270
Abstract
Synthesis of the decapeptide, histidylphenylalanylarginyltryptophylglycylserylprolylprolyl-lysylaspartic acid (I) corresponding to the C-terminal portion of β-melanocyte-stimulating hormones (β-MSH) from pig, sheep, beef, monkey and human was described. I was obtained by deformylation of histidylphenylalanylarginyltryptophylglycylserylprolylprolyl -Nε- formyllysylaspartic acid (II) with aqueous hydrazine. The MSH activity of I and II was examined in vitro. It was found that I and II exhibited the activity, 2.4×106 and 1.0×106 MSH U/g. respectively.This publication has 8 references indexed in Scilit:
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