THE EFFECT OF SODIUM CHLORIDE ADMINISTRATION UPON ADRENALECTOMIZED DOGS NOT RECEIVING EXTRACT

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Abstract
Feeding large quantities of NaCl to bilaterally adrenalectomized dogs prolonged the interval between cessation of cortical extract injections and development of adrenal insufficiency. 3 dogs remained free from symptoms 14 days, one 12 days, one 21 days, one 19, and one 50 days. The long surviving dog exhibited severe symptoms within a 4-day period following the withdrawal of salt from the diet. Intraperit. injections of large volumes of 0.85 or 0.9% saline failed to relieve the symptoms of severe insufficiency, but were effective in dogs exhibiting mild or moderate insufficiency; the blood pressure, blood urea N, and Hb having been restored to their normal levels by such treatment. NaCl and water cannot be regarded as an efficient substitute for the cortical hormone in the bilaterally adrenalectomized dog since it was necessary to inject cortical extract in order to save the animals when they sooner or later developed severe symptoms.

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