The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region.

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Abstract
Southern blot analysis indicates that there are four sequences in the human genome related to the mouse t‐complex gene Tcp‐1. All four genes were cloned and partial sequencing showed that one of them was a functional gene, and the other three were pseudogenes. The human sequences were all approximately 90% related to each other and 82‐89% related to the mouse Tcp‐1a sequence. Human TCP1 cDNA clones from both fibrosarcoma and B cell lines confirmed that there was a single expressed gene. mRNA transcripts of different sizes were accounted for by two different polyadenylation signals. The human TCP1 gene shared some amino acid substitutions with the mouse t‐complex allele (Tcp‐1a) which were not found in Tcp‐1b. The functional human TCP1 gene was mapped, using a panel of somatic cell hybrids, as well as in situ analysis, to the long arm of chromosome 6 at 6q23‐qter and thus is not closely linked to the HLA complex on the short arm. For this reason and others it is unlikely that there is a human equivalent of the mouse t‐complex.