Studies on the Use of Activated Charcoal and Cholestyramine for Reducing the Body Burden of Polybrominated Biphenyls

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Abstract
Weanling male rats were exposed to a polybrominated biphenyl (PBB) mixture (Firemaster FF-1) in their diet so that they received 1 mg/kg per day for 6 mo. They were then fed a normal diet for 4 mo. Following this they were placed on diets containing activated charcoal (AC) or cholestyramine (CSA) for 6 mo. to evaluate the usefulness of these compounds in reducing body burdens of retained PBB. Periods of restricted caloric intake were also used in an effort to mobilize PBB stored in fat. Neither compound nor restricted caloric intake was effective in reducing tissue Br levels but CSA proved useful in preventing progression of chronic progressive nephropathy, a spontaneous lesion of aging rats.