“Annexinopathies” — A New Class of Diseases

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Abstract
The annexins were first described as a family of proteins in 1990,1 and they have since been extensively reviewed.2 Individual members of the family had previously been isolated, characterized, and assigned a variety of names. The nomenclature depended on the particular scientific discipline of the investigators or on the tissue from which the proteins had been isolated. The proteins included the placental anticoagulant proteins, placental proteins, vascular anticoagulant proteins, lipocortins, and endonexins. With amino acid and nucleotide sequencing came the recognition that these various proteins were highly homologous and shared the property of binding calcium and phospholipids. So far, over . . .