Verney Was Right, but . . .

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Abstract
The differential diagnosis of nonglucosuric polyuria (i.e., of diabetes insipidus) presents us with an ironic twist. In many ways, it is a prototype of the application of basic scientific principles to the diagnosis of disease. In the form of the Hickey–Hare test or of its modification, the water-deprivation test,1 this differential diagnosis is in effect a repetition of the classic experiments of E. B. Verney, who defined the osmoregulatory system for the secretion of antidiuretic hormone (ADH, or vasopressin).2 And yet, despite this logic, these tests fail to yield the correct diagnosis in a rather large proportion of patients.3 , 4 As . . .

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