Oxalosis: An Unusual Cause of Myelophthisis in Childhood

Abstract
In a child with renal failure and oliguria due to hyperoxaluria myelophthisis developed as a result of extensive bone-marrow replacement with calcium oxalate crystals and an accompanying fibrous proliferation. The histopathology associated with this metabolic disorder was demonstrated in posterior iliac crest bonemarrow trephine biopsies, renal biopsies, and nephrectomy specimens. Crystals were demonstrated in biopsy specimens of transplanted kidneys within six weeks following renal transplantation.

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