Calcitonin‐producing insulinoma: clinical, immunocytochemical and cytogenetical study
- 1 August 1994
- journal article
- case report
- Published by Wiley in Clinical Endocrinology
- Vol. 41 (2) , 257-260
- https://doi.org/10.1111/j.1365-2265.1994.tb02539.x
Abstract
The case of a patient with a large goitre associated with hypercalcitoninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (CT) became normal. The tumour cells displayed a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a translocation t(1;9) (p13;p22).Keywords
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