Development of antibody to measles virus polypeptides during complicated and uncomplicated measles virus infections

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Abstract
Immune precipitation of 181 sera from 152 patients with natural measles was studied to determine the temporal course and frequency of antibody responses to nucleocapsid, fusion, hemagglutinin and matrix proteins of measles virus. Large amounts of antibody to nucleocapsid protein developed in all patients by day 1 of the rash. Antibody to hemagglutinin and fusion proteins developed in all patients over the next 3 wk, the former to high levels and the latter to low levels. Antibody to matrix protein developed to very low levels and was detectable in only 41% of the patients; this poor response to matrix protein was not correlated with the age of the patient or the acute neurological complications of measles.

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