The Clinical Usefulness of ACTH and Cortisone

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Abstract
Acute Rheumatic Fever Hench et al.9 were the first to demonstrate a dramatic improvement in patients with acute rheumatic fever treated with Cortisone. The dosage employed was 200 mg. daily at first and subsequently 100 mg. daily in 3 adolescent patients. The total period of treatment exceeded twenty-one days in all cases. Marked clinical improvement was observed within forty-eight hours of the initiation of therapy, whereas the sedimentation rate did not attain a normal value for ten to twenty days. These observations were all confirmed with the use of ACTH by Thorn et al.,36 who demonstrated the effectiveness of relatively . . .