An RNA-Guided Pathway for the Epigenome
- 27 September 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5590) , 2215-2218
- https://doi.org/10.1126/science.1077903
Abstract
How does the cell maintain the huge areas of the genome containing DNA repeats in its heterochromatin form? As [Thomas Jenuwein][1] discusses in his indepth Perspective, new clues have arrived from the fission yeast ([Hall][2] et al .) and the ciliated protozoan Tetrahymena . These organisms reveal that small heterogeneous RNAs formed at DNA repeats in the nucleus are important for initiating and maintaining heterochromatin. [1]: http://www.sciencemag.org/cgi/content/full/297/5590/2215 [2]: http://www.sciencemag.org/cgi/content/short/297/5590/2232Keywords
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