Cross-Resistance Among 3 Tetracyclines.

Publisher Website
Google Scholar
Abstract
Organisms made resistant in vitro to either tetracycline or oxytetracycline by repeated subcultures in these antibiotics developed essentially complete cross-resistance to each other and to chlortetracycline. No cross-resistance or increases in sensitivity to penicillin, streptomycin, bacitracin, polymyxin, neomycin or erythromycin developed as a result of increases in resistance to the tetracyclines. Three strains of coliform bacilli each showed significant cross-resistance to chloramphenicol following sub-cultures in either tetracycline or oxytetracycline, but similar cross-resistance was not observed in 5 gram-positive coccal strains.