INSULIN CONCENTRATION IN PORTAL AND PERIPHERAL VENOUS BLOOD AFTER ORAL GLUCOSE IN HUMAN PANCREATITIS

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Abstract
Insulin and glucose concentrations in the portal and in the peripheral venous blood have been determined in connection with oral glucose loads in 12 patients with acute or relapsing acute pancreatitis. A low insulin increase in the peripheral venous blood was not invariably accompanied by a poor insulin increase in the portal blood, but was sometimes due to a substantial reduction of the insulin level between the portal and the peripheral venous blood. Moreover, the fractional reduction of insulin between the portal and the peripheral venous blood tended to be higher at a high than at a low portal insulin level. The blood glucose concentration, however, seemed to be without influence upon the relation between the portal and the peripheral venous insulin concentrations.