PHARMACOKINETIC EVALUATION OF ICI 35 868 IN MAN

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Abstract
Blood concentrations of ICI 35 868 have been measured in patients following a single bolus dose of 2 mg kg−1. Three different rates of injection of the anaesthetic agent (3–5s, 20s and 40 or 50s) were examined. Pharmacokinetic indices, derived from blood concentrations of ICI 35 868, were independent of the speed of injection. The blood profiles could be described by a two-compartment open model with a mean a-phase half-life of 2.5min and a mean β-phase half-life of 54.5min. The mean total body clearance was 3454 ml min−1. Similar data were obtained from a 4-mgkg−1 dose. The mean recovery time (4.4 min) and concentration of ICI 35 868 at awakening (1.05 üg ml−1) were also independent of the rate of injection. Using the derived pharmacokinetic model, predictions of drug concentrations have been made for repeated bolus doses, or infusions, of ICI 35 868