Effect of Prostaglandins E1 E2 and E2α on the Electric Activity of the Sphincter of Oddi in Living Rabbit

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Abstract
The effect of prostaglandins (PGs), i.e. PGE1 PGE2 and PGF2α (0.5–32 µg/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PGs were injected intravenously as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were also studied at the same time. PGE1 strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF2α·Both PGE1 and PGF2α showed a dose-response curve of Michaelis-Menten type. Unexpectedly PGE2 increased at first then decreased electrical activity but not significantly. These effects appeared very early after intravenous injection and were evident with low doses.