Estimating multipoint recombination fractions
- 1 July 1995
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 59 (3) , 307-321
- https://doi.org/10.1111/j.1469-1809.1995.tb00750.x
Abstract
SUMMARY: The likelihood in linkage investigations can be expressed as a polynomial in the relevant recombination fractions. With polymorphic characters, this can be reduced to a product of separate factors for female and male recombinations, with only mild loss of information. With three generation data the polynomials take a specially simple form. Algorithms are given for finding maximum likelihood estimates and their standard errors.Keywords
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