The metabolism of C14‐α‐tocopheryl quinone and C14‐α‐tocopheryl hydroquinone
- 1 September 1967
- Vol. 2 (5) , 390-396
- https://doi.org/10.1007/bf02531852
Abstract
The metabolism of C14‐d‐α‐tocopheryl quinone (α‐TQ) and its hydroquinone (αTHQ) was investigated. Forty‐six hours after intraperitoneal administration of either compound to rats the radioactivity isolated from the liver was present almost exclusively in C14‐α‐TQ. The results indicated, however, that in situ this compound was present primarily in the reduced form. No conversion to C14‐α‐tocopherol or other liver metabolites was observed. α‐THQ was eliminated from the tissues more rapidly than α‐TQ. The main metabolite excreted in the urine was a conjugate of α‐tocopheronic acid and the main metabolite excreted in the feces was a conjugate of α‐TQ. Free C14‐α‐TQ was present in the feces after administration of this compound but not after C14‐α‐THQ administration.This publication has 22 references indexed in Scilit:
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