UREA METABOLISM IN MAN*
Open Access
- 1 September 1959
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 38 (9) , 1617-1626
- https://doi.org/10.1172/jci103940
Abstract
Urea labeled with N15 or C14 was injected intravenously into normal subjects and its disappearance from blood and urine was observed. The calculated rate of urea production exceeded the measured rate of urea excretion by 20%. Approximately 1/4 of the labeled urea was not recovered in the urine. The true rate of breakdown is probably greater, since there was evidence that labeled atoms of N15, and possibly C14, were reincorporated. Following oral neomycin administration, urinary recovery of C14-labeled urea became nearly complete. Apparently at least 1/4 of synthesized urea is continuously being hydrolyzed by intestinal bacteria in normal subjects.Keywords
This publication has 14 references indexed in Scilit:
- Clinical Experience with the Use of Neomycin in Hepatic ComaArchives of internal medicine (1960), 1959
- The reliability of estimated rates of production in simple turnover experimentsArchives of Biochemistry and Biophysics, 1957
- CARBON DIOXIDE FIXATION AND UREA SYNTHESIS IN THE RATJournal of Biological Chemistry, 1956
- Carbon isotope effects in enzyme systems. I. Biochemical studies with ureaseArchives of Biochemistry and Biophysics, 1956
- The Fate of Urea in Growing Pigs , ,Journal of Nutrition, 1955
- BLOOD-AMMONIA LEVELS IN RELATION TO HEPATIC COMA AND THE ADMINISTRATION OF GLUTAMIC ACIDThe Lancet, 1954
- Breakdown of Urea in the RatExperimental Biology and Medicine, 1953
- The Effect of Antibiotics on Urea Breakdown in MiceProceedings of the National Academy of Sciences, 1953
- Determination of Renal Clearance of RadioiodineJournal of Applied Physiology, 1950
- Metabolism of C 14 -1abeled UreaScience, 1948