Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin
Open Access
- 30 September 1990
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 33 (10) , 1554-1559
- https://doi.org/10.1002/art.1780331013
Abstract
Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.This publication has 14 references indexed in Scilit:
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