Studies on the Biosynthesis of Spirostaphylotrichin A
- 14 June 1989
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 72 (4) , 774-783
- https://doi.org/10.1002/hlca.19890720418
Abstract
Incorporation of 14C‐labelled acetate and amino acids as well as of [1‐13C]‐, [2‐13C]‐, and [1,2‐13C2] acetate, L‐[methyl13C] methionine, [2,3‐13C2] succinate, and L‐[2,3‐13C2] aspartate into spirostaphylotrichin A (1) by Staphylotrichum coccosporum demonstrates that the building blocks of 1 are 5 units of acetate/malonate, 1 unit of methionine, and a C4‐dicarboxylic acid. The latter is most likely aspartate and derived from the citric‐acid cycle. Using [2‐13C, 2‐2H3] acetate as a precursor, the starter unit of the polyketide chain was identified.This publication has 21 references indexed in Scilit:
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