Relationship of Sodium Retention to Potassium Excretion by the Kidney During Administration of Desoxycorticosterone Acetate to Dogs

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Abstract
A negative K balance and hypokalemia developed during desoxycorticosterone acetate (DCA) administration to normal dogs on a moderate or high Na intake; on a low Na diet, the response failed to occur. No alteration in K balance or plasma K occurred as a result of DCA therapy in dogs with thoracic inferior caval constriction on a moderate Na intake. Failure of urinary K excretion to increase during DCA administration might result from almost complete reabsorption of Na and Cl in the renal tubules proximal to the site of Na and K exchange.