THE INFLUENCE OF THE THYROID ON CEREBRAL METABOLISM*

Publisher Website
Google Scholar
Abstract
THE changes in mental activity associated with abnormal thyroid states have usually been explained on the basis of alterations in cerebral metabolism due directly to local excess or deficiency of the thyroid hormone. Such reasoning has received a certain amount of experimental support, if only by analogy. McEachern (1935) has demonstrated a significant increase in the oxygen consumption of liver, kidney, and diaphragm after administration of thyroxin. Jandorf and Williams (1944) using thyrotropic hormone, reported a 50 to 100 per cent increase in oxygen consumption of liver and muscle. (These investigators using adult animals were unable to show any decrease in oxygen consumption in the same tissues following thiouracil administration.) Cohen and Gerard (1937) observed a 30 per cent increase in the cerebral oxygen consumption of animals given thyroxin. In a preliminary study (Fazekas, 1946) we were unable to demonstrate any acceleration of the cerebral oxygen consumption in hyperthyroid rats,

This publication has 4 references indexed in Scilit: