Increased production of platelet thromboxane B2 in non‐insulin‐dependent diabetes. Relationship to vascular complications

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Abstract
Platelet thromboxane B2 production was studied in forty‐seven non‐insulin‐dependent diabetics by incubating platelets with increasing concentrations of arachidonic acid. In comparison with thirty‐two healthy subjects, diabetics showed increased thromboxane B2 production at 0·7 mmol/l (mean: 236 pmol/108 platelets, SEM 201–277; v. 135, 105–174; P < 0·05) and at 1·0 mmol/l (673, 613–739; v. 405, 377–486, P < 0·01) but not at 0·5 mmol/l. Patients were subdivided according to the presence or absence of vascular complications. Patients without microangiopathy showed significantly greater thromboxane B2 production than healthy subjects at all the arachidonic‐acid concentrations (P < 0·02 or less). Patients with microangiopathy had platelet thromboxane production similar to that observed in healthy subjects at all the arachidonic‐acid concentrations (P > 0·30) but significantly lower than that of non‐microangiopathic patients at 0·5 (P < 0·01) and at 0·7 mmol/l arachidonic acid (P < 0·05). These results indicate that non‐insulin‐dependent diabetics have increased production of platelet thromboxane B2 only when they do not have microvascular complications.

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