Chronic Effect of Dietary Protein on Hypercholesteremia in the Rat.

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Abstract
Adult rats were fed a diet containing 1.2% cholesterol, 15% lard and varying levels of casein. The casein level was varied at the expense of dextrin in 8 dietary groups of 8 to 23 animals. The animals were sacrificed after 6 months on these diets when they were autopsied and blood was obtained for individual serum cholesterol and lipid phosphorus de- terminations. Mean serum cholesterol was higher at 7.5 and 9% levels of dietary casein than at the 12.5% level and it was higher at 25% and 40% levels than at 18.75% dietary casein. The cholesterol:lipid phosphorus ratio was lower with the low casein levels than at optimal or higher levels of casein. The 9 animals fed 40% casein developed a mean serum cholesterol level of 490 mg %. Three of these animals developed coronary atheromatous lesions which were not seen in any of the other groups after such a short period.

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