Aldosterone Deficiency in Chronic Renal Failure

Publisher Website
Google Scholar
Abstract
A case of isolated hypoaldosteronism associated with chronic renal failure is reported. Potassium retention and hyperkalemia, sodium wasting, and inability to acidify the urine were all corrected by mineralocorticoid administration. Aldosterone secretion was 86.0 µg/day on a high sodium intake, 30.1 µg/day on a low sodium intake, and 36.2 µg/day after an angiotensin infusion. An important physiologic role is postulated for the hypersecretion of aldosterone usually seen in patients with chronic renal failure.