Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.
- 1 June 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (6) , 2657-2664
- https://doi.org/10.1128/mcb.9.6.2657
Abstract
We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression. ImagesThis publication has 41 references indexed in Scilit:
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