T cell-mediated immunity in murine malaria. II. Induction of protective immunity to P. chabaudi by antigen fed macrophages and antigen educated lymphocytes

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Abstract
Assay systems for generating antigen specific proliferating T cells to P. chabaudi antigens were previously examined. Whether the various sensitization approaches confer immunity against a cloned virulent strain IP-PCI of P. chabaudi. Effective specific protective immunity can be induced through P. chabaudi antigen fed macrophages and antigen educated spleen cells (initiator lymphocytes). The expression of this protective immunity is proposed to depend on antigen presentation and/or accessory function of macrophages and the subsequent activation of T cell functions related to protection. Indeed analysis of different macrophage populations revealed a correlation between the expression of Ia molecules and IL-1 secretion with their capacity to induce antigen specific T cells in vivo and subsequent protective immune mechanisms. These results emphasize the critical functions of accessory cells in determining the outcome of malaria infections.