Effect of mdr1a P-Glycoprotein Gene Disruption, Gender, and Substrate Concentration on Brain Uptake of Selected Compounds
- 1 January 2001
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 18 (7) , 957-963
- https://doi.org/10.1023/a:1010984110732
Abstract
Purpose. This study assessed the influence of mdr1a P-glycoprotein (P-gp) gene disruption, gender and concentration on initial brain uptake clearance ( Clup) of morphine, quinidine and verapamil. ...Keywords
This publication has 25 references indexed in Scilit:
- Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serumJNCI Journal of the National Cancer Institute, 1998
- Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatmentInternational Journal of Cancer, 1998
- 17 beta-Estradiol modulation of glucose transporter 1 expression in blood-brain barrierAmerican Journal of Physiology-Endocrinology and Metabolism, 1997
- Interaction of Structurally Diverse Pesticides with the HumanGene Product P-GlycoproteinToxicology and Applied Pharmacology, 1996
- Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and VinblastineJournal of Neurochemistry, 1996
- Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.1996
- Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.1996
- Intravenous verapamil kinetics in rats: Marked arteriovenous concentration difference and comparison with humansBiopharmaceutics & Drug Disposition, 1993
- Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterusMolecular Reproduction and Development, 1990
- Gender Differences in Regional Cerebral Blood FlowSchizophrenia Bulletin, 1990