EFFECTS OF EXOGENOUS AND ENDOGENOUS POSTERIOR PITUITARY ANTIDIURETIC HORMONE ON WATER AND ELECTROLYTE EXCRETION 1

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Abstract
A comparison of the effects of pitressin given intraven. and endogenously produced ADH was made in subjects receiving 0.8 to 0.9% saline soln. The effects on the excretion of water, Na and chloride are similar. Commercial ADH (pitressin) given intraven. in small doses causes a slight decrease in the excretion of Na in water-loaded subjects in whom urine flow is reduced to around 1 cc./min. No effect was demonstrable in water-loaded subjects receiving inulin and PAH for clearance studies or in salt-loaded subjects. After salt loading pitressin caused a transient increase in the excretion of K. The urine volume after intraven. pitressin is influenced by the excretion of amts. of Na and chloride in the urine which are within the physiol. range. Small doses of pitressin given intraven. have no effect on glomerular filtration rate and renal plasma flow.