Biochemical Differentiation in Reaggregating Brain Cell Culture
- 1 August 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (8) , 1858-1861
- https://doi.org/10.1073/pnas.68.8.1858
Abstract
Dissociated cells from embryonic mouse brain reassociate in rotation culture to form aggregates. During cell culture the specific activities of choline acetyl-transferase (EC 2.3.1.6), acetylcholinesterase (EC 3.1.1.7), and glutamate decarboxylase (EC 4.1.1.15) in the aggregates increase up to twenty-fold, a phenomenon that approximates some of the biochemical events in the development of the mouse brain.Keywords
This publication has 16 references indexed in Scilit:
- Histogenesis of fetal mouse isocortex and hippocampus in reaggregating cell culturesDevelopmental Biology, 1970
- L-Glutamic Acid Decarboxylase: A New Type in Glial Cells and Human Brain GliomasScience, 1970
- Differentiated Rat Glial Cell Strain in Tissue CultureScience, 1968
- The formation of synaptic junctions in developing rat brain: A quantitative electron microscopic studyBrain Research, 1967
- Changes of mitochondrial glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase during brain developmentBiochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
- Some properties of L-glutamic decarboxylase in mouse brainBiochemical Pharmacology, 1963
- QUANTITATIVE HISTOCHEMICAL STUDIES OF THE MORPHOGENESIS OF THE CEREBELLUM I—TOTAL LIPID AND FOUR ENZYMES*Journal of Neurochemistry, 1961
- QUANTITATIVE HISTOCHEMICAL CHANGES DURING THE DEVELOPMENT OF THE RAT CEREBRAL CORTEX*Journal of Neurochemistry, 1956
- -Aminobutyric Acid Content and Glutamic Decarboxylase Activity in Developing Mouse BrainExperimental Biology and Medicine, 1951
- The Determination of Cholinesterase Activity in Whole Brains of Developing RatsScience, 1951