Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans
- 1 September 1984
- journal article
- review article
- Published by Springer Nature in Clinical Rheumatology
- Vol. 3 (3) , 361-364
- https://doi.org/10.1007/bf02032343
Abstract
From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblastsin vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.Keywords
This publication has 26 references indexed in Scilit:
- Chronic arthritis associated with the presence of intrasynovial rubella virus.Annals of the Rheumatic Diseases, 1983
- Inhibition by Glucocorticosteroid Hormones of Interferon and Prostaglandin E Induction by Poly(rI).Poly(rC)Journal of General Virology, 1982
- Interferons and Interferon InducersDrugs, 1982
- THE ROLE OF INTERFERON IN IMMEDIATE HYPERSENSITIVITY AND AUTOIMMUNE DISEASESAnnals of the New York Academy of Sciences, 1980
- Stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblastsArthritis & Rheumatism, 1980
- Immune Interferon in the Circulation of Patients with Autoimmune DiseaseNew England Journal of Medicine, 1979
- Acute induction of joint inflammation in the rat by Poly I · Poly CInflammation, 1979
- Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferonArthritis & Rheumatism, 1976
- Virus antibody in synovial fluid of rheumatoid and control patients.Annals of the Rheumatic Diseases, 1974
- Virologic Studies on Rheumatoid ArthritisArthritis & Rheumatism, 1973