Dexamethasone Effect on the Phospholipid Content of Isolated Fat Cell Ghosts from Adrenalectomized Rats
- 1 September 1979
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 105 (3) , 774-777
- https://doi.org/10.1210/endo-105-3-774
Abstract
The lipid composition of sonicated ghosts from isolated fat cells has been investigated. Epididymal fat cells from adrenalectomized rats were incubated with and without 8 × 10-8 M dexamethasone for 3 h. Phospholipids and cholesterol were isolated from membrane ghosts prepared from these cells. There was a 61% increase in membrane sphingomyelin from cells incubated with dexamethasone (P < 0.025). No significant change was observed in other phospholipids, cholesterol, or fatty acid components of the phospholipids.Keywords
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